This study was made to understand a hypoglycemic action of the fat soluble fraction of Panax ginseng C. A. Meyer in streptozotocin induced diabetic rats by determining the activities of several enzymes related to carbohydrate and lipid metabolism
as
well as several blood component levels such as glucose and ketone bodies, and non-esterified fatty Albino rats (Sprague Dawley, 170~200g, ♂) were injected once with 70mg streptozotocin/kg body weight intraperitoneally and fed with ordinary diet
for 7
days, and then the fat soluble fraction (5mg~20mg/day/rat) was injected intraperitoneally once a day for three days to rats having high blood glucose level over 340mg/100ml. After a final injection of the fat soluble fraction, rats were starved
for
16
hours followed by the analysis of blood serum and liver enzymes. It was found that increased levels of glucose, ketone bodies and free fatty acids in streptozotocin induced rats were decreased appreciably by administration of the fat soluble
fraction.
However, the amount of administered fat soluble fraction did not show any significantly different hypoglycemic action. Decreased activities of glucokinase, phosphofructokinase, pyruvate kinase, 6-phosphogluconate dehydrogenase and acetyl CoA
carboxylase
of the liver of streptozotocin induced diabetic rats were greatly modified suggesting that a hypoglycemic action of the fat soluble fraction was also appreciable as ginseng saponin fraction We also compared a hypoglycemic action of the fat
soluble
Traction prepared from American ginseng and Chinese ginseng with that of Korean panax ginseng No significant difference of the hypoglycemic activity was observed beetween the above ginseng fat soluble fractions, suggesting that a study of the fat
soluble fraction might be one of the most interesting subjects relating to diabetic hyperglycemia in the near iutare.
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